Research Paper: Intracellular Penetration of Atazanavir, Ritonavir and Dolutegravir With Concomitant Rifampicin: A Dose Escalation Study
1 February 2025
The results from this study confirmed that the dose escalation strategy is capable of restoring ATV/r concentrations within the intracellular compartment comparable to those observed before the introduction of rifampicin, providing an important validation to the evidence from the plasma compartment, with pharmacodynamic and clinical implications.