Research Paper: Model-based evaluation of the interaction between ritonavir-boosted atazanavir and rifampicin in Ugandan adults with HIV

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Abstract: The DERIVE study (NCT04121195) recruited Ugandan adults with HIV (not TB) on ATV/r-based second-line antiretroviral therapy, and collected intensive plasma and PBMC pharmacokinetic samples during four visits with a sequential dose-escalation design. ATV/r plasma and PBMC concentrations were analysed with population pharmacokinetic modelling in NONMEM.

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