Tag: Seminar

A dive into pharmacokinetics modelling of drugs in global health research: Dr. Karen Yeo presents a case study on Moxidectin

My name is Joshua Kiptoo, a member of the Uganda chapter of Pharmacometrics Africa and a practicing clinical pharmacist in Uganda.  Like many other life concepts, I have appreciated that “how” one communicates a scientific concept is as (if not more) important as “what” one intends to communicate. To me, unraveling the ‘how‘ when communicating the concept of “modeling” is critical in understanding the growing popularity of pharmacokinetic modeling in the past decades. Not only is the phrase “Physiologically Based Pharmacokinetic (PBPK) modeling” a mouthful of words to fit in one breath, but also a concept that sounds complex at the first hearing. Thinking about how people facilitate understanding of perceived ‘complex’ subjects like PBPK modeling, the idea that rang ‘closest to home’ was the use of human mannequins in our clothes shopping stores. In Uganda, tailoring is still a big business and most of us will have our clothes designed and tailor-made for ‘that’ special occasion. To best select tailor-made clothes that best fits an individual’s preference, a vendor may require a mannequin as an additional investment in the business. You can only better appreciate your potential clothes when hung on an appropriate mannequin (‘model’) with the right shape, size, and design (‘dosage regimen’) that is most likely to meet your individual needs. Quite often, we look at the chest and shoulders designs, the waist size, and overall height of the clothing on display. Such is the concept of modeling, and a model that better suits the needs of

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PMX Africa
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