I. Methodology & Workflows

III. Population Pharmacokinetic modelling

Early Pharmacokinetics of High Dose Rifampicin in Critically ill Patients with HIV Associated TB

Avuyonke Balfour (1), Phiona E Namale (2,3), Lufina Tsirizani (1), Paolo Denti (1), Charlotte Schutz (2, 3), Gary Maartens (1, 3), Graeme Meintjes (2, 3)

III. Population Pharmacokinetic modelling

Characterizing Slow-Release Metformin Pharmacokinetics Using Transit Compartment Absorption: A Population Modeling Approach

Rohan M Benecke(1), Mohammed Wulgo Ali(1), Veshni Pillay-Fuentes Lorente(1), Eric Decloedt(1), Roland van Rensburg(1)

V. Reviews

A Systematic Review of Published Physiological Based Pharmacokinetic (PBPK) Models in Human Lactation: Knowledge Gaps & Opportunities for Optimization of Reporting Practices

Joshua Kiptoo (1) (2) , Davies Otieno (1), (2) , Kenta Yoshida (3) , Neel Deferm (4) , Aida N. Kawuma (2) , Francis William Ojara (2) (5) , Adeniyi Olagunju (6) , Jackson Mukonzo (1) , Catriona Waitt (2) (7)

V. Reviews

Pharmacometrics in HIV/AIDS Research in Africa: A Systematic Review of Current Evidence

Jeremiah Oluwamayowa Omojuyigbe (1), Taiwo Olatunji Waris (1), Timothy Temiloluwa Orimolade (1)

III. Population Pharmacokinetic modelling

Pharmacogenetic Determinants of Efavirenz Clearance in Nigerians Living with HIV: Insights from Population PK Modeling

Jacinta N. Nwogu-Attah (1) Adeniyi Olagunju (2), Chinedum P. Babalola (3),Laura Dickinson (2)

III. Population Pharmacokinetic modelling

Population Pharmacokinetic Characterization of Plasma to Breast Milk Transfer of Lamivudine and Subsequent Infant Exposure Through Breast Milk

Francis W. Ojara (1) (2), Aida N. Kawuma (1), Ritah Nakijoba (1) , Shadia Nakalema (1) , Isabella Kyohairwe (1), Mohammed Lamorde (1) , Henry Pertinez (3) , Saye Khoo (3) , Catriona Waitt (1) (3)

III. Population Pharmacokinetic modelling

Pharmacokinetics of Ethambutol and Weight Banded Dosing in South African Adults Newly Diagnosed with Tuberculosis and HIV

Bonginkosi Ndzamba [1], Paolo Denti [2], Helen McIlleron [2], Peter Smith [2], Thuli Mthiyane [4], Roxana Rustomjee [3], Philip Onyebujoh [5], Juan Eduardo Reséndiz-Galván [2]

III. Population Pharmacokinetic modelling

The Effect of Pregnancy and Breastfeeding on the Population Pharmacokinetics of Levofloxacin in South Africans with Rifampicin Resistant Tuberculosis

Sharon Sawe (1), Lufina Tsirizani (1), Kamunkhwala Gausi(1), Richard Court(1), Buyisile Mkhize (1), Tasnim Badat (2), Asanda Poswa (2), Lubbe Wiesner (1), Gary Maartens(1), Marian Loveday3,4, Catriona Waitt5,6, Francesca Conradie2, Paolo Denti1

III. Population Pharmacokinetic modelling

Population Pharmacokinetics of Plasma Tenofovir and Intracellular Tenofovir-Diphosphate in a South African Population: Exposure–Response Relationships and Biomarker-Based Adherence Strategies

Cassius Phogole (1), Lauren Jennings (2), Roland van Rensburg (1), Tracy Kellermann (1), Rohan Benecke (1), Veshni Pillay-Fuentes Lorente (1), Catherine Orrell (2,3), Gert van Zyl (4), Eric Decloedt (1), Joseph F Standing (1,5)

II. Physiologically Based Pharmacokinetic modelling

Can PBPK Modelling Solve the Postpartum Sepsis Pharmacokinetics Puzzle?

Davies Otieno (1) , Joshua Kiptoo (1), Aida Kawuma(1) , Francis Williams Ojara (1,2), Catriona Waitt (1,3)

III. Population Pharmacokinetic modelling

Population Pharmacokinetics Analysis of Ivermectin in Adolescents Infected with Trichuris trichiura: A Bayesian Modeling Approach

David T. Ajayi[1],[2], Ochuko M. Orherhe[1],[3], Goonaseelan (Colin) Pillai[1],[4],[5], Samer Mouksassi[1],[6], Britta Steffens[7], Dominic Bräm[7], Viviane Sprecher[8],[9], Daniela Hoffmann[8],[9], Michael Buettcher[7],[9],[10], Jean T. Coulibaly[11],[12], Said M. Ali[13], Jennifer Keiser[8],[9], Marc Pfister[7],[11]

III. Population Pharmacokinetic modelling

Optimising Intrapartum Benzylpenicillin Dosing: Insights from Population Pharmacokinetic Modelling

Bonniface Obura (1), Jennifer Unsworth (1), Ana Jimenez-Valverde (1), Catriona Waitt (2,3), William Hope (1), Shampa Das (1), Kate Navaratnam (4,5)

I. Methodology & Workflows

Evaluation of Various Methods of Handling BQL Data in Population PK: Desipramine Case Study

Bonginkosi S’fiso Ndzamba [1,3], Innocent Gerald Asiimwe [2,3], Samer Mouksassi [4], Goonaseelan (Colin) Pillai [3,5,6], Aurelie Lombard [7], Jennifer Lang [8]

VIII. Disease modeling

Genetic Polymorphisms and Expression Profiles of IL28B and FOXP3Predict Response to Direct Acting Antivirals in Chronic Hepatitis C Patients

Aya I. Abdelaziz (1), Eman Abdelsameea (2), Mohamed Abdel-Samiee (2), Samar E. Ghanem (3), Sara A. Wahdan (4) ,Doaa Elsherbiny (4), Zeinab Zakaria (5,1), Samar S. Azab (4)

III. Population Pharmacokinetic modelling

Population PK & Model Based Vancomycin Dose Optimization in Sudanese Adults with Renal Impairment

Khalid Altigani Ahmed (1) , Alnada Ibrahim (2) , Daniel Gonzalez (3) , Abubakr O Nur (4)

III. Population Pharmacokinetic modelling

Population pharmacokinetics of first-line TB drugs in Haitian children under5 years old, and accuracy of finger stick capillary sampling technique

H. Waalewijn (1), L. Tsirizani (1), P. Denti (1), V. Dartois (3), M. Zimmerman (4), M.H. Lee (5), N. Alcenat (6), N. Haba (5), D. Fitzgerald (50, J.W. Pape (6), J. Mathad (5), V. Rouzier (2)

V. Reviews

Harnessing Electronic Health Records to Advance Pharmacometrics Based Clinical Decision Making: A Systematic Review

Noel Patson (1) (2) Francis Chiumia (2)

I. Methodology & Workflows

Towards the Best Practices to Create Virtual Healthy Control Populations for Organ Impairment Studies

Ronald Kadada Karyaburo (1) (2), Mohammed Wulgo Ali (3), Islam R. Younis (4) , Dan Li (4) , Roeland E. Wasmann (5)

II. Physiologically Based Pharmacokinetic modelling

Physiologically Based Pharmacokinetics model to Elucidate food effects on the absorption pharmacokinetics of Metformin in an Adult Population

Martin Mutaka (1), Josua Kiptoo (1) (2), Jackson Mukonzo (1) Ian Haworth (3)

VI. Regulatory

Don’t Fantasize, strategize: A Regulatory Framework for Model Informed Drug Development (MIDD) To Empowering African Drug Development

Nouran Elkheshen (1) , Rania Shosha (2)

II. Physiologically Based Pharmacokinetic modelling

Development and Validation of a Physiologically Based Pharmacokinetic (PBPK) Model for Hydroxyurea Dose Evaluation in Nigerian Adult Sickle Cell Disease Patients

Ochuko Maureen Orherhe (1), Olamide Eniola Ilegbemi (1), Taiwo Favour Odumesi (1), Babajide Shenkoya (2), Babatunde Ayodeji Adeagbo (3)

II. Physiologically Based Pharmacokinetic modelling

Model based assessment of the kinetics of coproporphyrin I (CPI), an endogenous biomarker of OATP 1 B transporter, in a Dose Escalation Study of GDC X

Sadikalmahdi Abdella (1), Susan Nyabate (2), Amira Ghoneim (3), Samer Mouksassi (4), Goonaseelan (Colin) Pillai (5), Sravanthi Cheeti (6), Kenta Yoshida (6)

VIII. Disease modeling

ML methods ease computation and accelerate covariate screening

Safaa A. Ibrahim (1), Jennifer Lang (3), Innocent Asiimwe (1), Samer Mouksassi (4) (5), Goonaseelan (Colin) Pillai (1) (6), Sergey Shcherbinin (7), Ivelina Gueorguieva (3) (7), Alzehimer’s Disease Neuroimaging Initiative (8)

I. Methodology & Workflows

Forestplots to inform label dosing recommendations should not be done using EBEs: A Tutorial

Samer Mouksassi [1], Amira Ghoneim [2].

III. Population Pharmacokinetic modelling

Population Pharmacokinetics of the Interaction between Atazanavir/Ritonavir and Tizoxanide from Oral Nitazoxanide in Healthy Volunteers

Babatunde Mubarak Junadu (1) Babatunde Adeyogi Adeagbo (1) Ochuko Maureen Orherhe (2) Abdulafeez Akinloye (1)

V. Reviews

Clinical evidence and recommendation on the use of Type-2 Diabetes Mellitus drugs in Lactation

Katherine Richardson (1), Joshua Kiptoo (2) (3), Beatrice Mpora Odongkara (4), Francis Williams Ojara (2) (5), Catriona Waitt (2) (6)

III. Population Pharmacokinetic modelling

Optimising Amodiaquine Dosing in Nigeria: A Population Pharmacokinetic Study to Inform Seasonal Malaria Chemoprevention

Babatunde Ayodeji Adeagbo (1) Ochuko Maureen Orherhe (2), Oluseye Oladotun Bolaji (1)

VII. Education

Advancing Pharmacometrics Capacity in Africa: Insights from the Applied Pharmacometrics Training Fellowship Program and Key Research Outputs

Wynand Smythe [1], Innocent Asiimwe [2,3], Ochuko Orherhe [4], Amira Ghoneim [1], Rik de Greef [1], Samer Mouksassi [2,5], Goonaseelan (Colin) Pillai [2,6,7]

Early Pharmacokinetics of High Dose Rifampicin in Critically ill Patients with HIV Associated TB

Characterizing Slow-Release Metformin Pharmacokinetics Using Transit Compartment Absorption: A Population Modeling Approach

A Systematic Review of Published Physiological Based Pharmacokinetic (PBPK) Models in Human Lactation: Knowledge Gaps & Opportunities for Optimization of Reporting Practices

Pharmacometrics in HIV/AIDS Research in Africa: A Systematic Review of Current Evidence

Pharmacogenetic Determinants of Efavirenz Clearance in Nigerians Living with HIV: Insights from Population PK Modeling

Population Pharmacokinetic Characterization of Plasma to Breast Milk Transfer of Lamivudine and Subsequent Infant Exposure Through Breast Milk

Pharmacokinetics of Ethambutol and Weight Banded Dosing in South African Adults Newly Diagnosed with Tuberculosis and HIV

The Effect of Pregnancy and Breastfeeding on the Population Pharmacokinetics of Levofloxacin in South Africans with Rifampicin Resistant Tuberculosis

Population Pharmacokinetics of Plasma Tenofovir and Intracellular Tenofovir-Diphosphate in a South African Population: Exposure–Response Relationships and Biomarker-Based Adherence Strategies

Can PBPK Modelling Solve the Postpartum Sepsis Pharmacokinetics Puzzle?

Population Pharmacokinetics Analysis of Ivermectin in Adolescents Infected with Trichuris trichiura: A Bayesian Modeling Approach

Optimising Intrapartum Benzylpenicillin Dosing: Insights from Population Pharmacokinetic Modelling

Evaluation of Various Methods of Handling BQL Data in Population PK: Desipramine Case Study

Genetic Polymorphisms and Expression Profiles of IL28B and FOXP3Predict Response to Direct Acting Antivirals in Chronic Hepatitis C Patients

Population PK & Model Based Vancomycin Dose Optimization in Sudanese Adults with Renal Impairment

Population pharmacokinetics of first-line TB drugs in Haitian children under5 years old, and accuracy of finger stick capillary sampling technique

Harnessing Electronic Health Records to Advance Pharmacometrics Based Clinical Decision Making: A Systematic Review

Towards the Best Practices to Create Virtual Healthy Control Populations for Organ Impairment Studies

Physiologically Based Pharmacokinetics model to Elucidate food effects on the absorption pharmacokinetics of Metformin in an Adult Population

Don’t Fantasize, strategize: A Regulatory Framework for Model Informed Drug Development (MIDD) To Empowering African Drug Development

Development and Validation of a Physiologically Based Pharmacokinetic (PBPK) Model for Hydroxyurea Dose Evaluation in Nigerian Adult Sickle Cell Disease Patients

Model based assessment of the kinetics of coproporphyrin I (CPI), an endogenous biomarker of OATP 1 B transporter, in a Dose Escalation Study of GDC X

ML methods ease computation and accelerate covariate screening

Forestplots to inform label dosing recommendations should not be done using EBEs: A Tutorial

Population Pharmacokinetics of the Interaction between Atazanavir/Ritonavir and Tizoxanide from Oral Nitazoxanide in Healthy Volunteers

Clinical evidence and recommendation on the use of Type-2 Diabetes Mellitus drugs in Lactation

Optimising Amodiaquine Dosing in Nigeria: A Population Pharmacokinetic Study to Inform Seasonal Malaria Chemoprevention

Advancing Pharmacometrics Capacity in Africa: Insights from the Applied Pharmacometrics Training Fellowship Program and Key Research Outputs

Poster Categories