Category: University of Cape Town

Applications CLOSED: PhM-2026 Online Pharmacometrics Course

17 July 2026

New applications are closed – thank you for your interest Thank you for your interest in the course – we have had unprecedented interest in the course and, as a result, a significant backlog of emails and acceptance letters to process. We thank you in advance for your patience. Call for applications Pharmacometrics Africa Africa invites applications for PhM-2026, a supported online pharmacometrics course delivered through the PMXAfrica Moodle platform. About this series PhM-2026 builds on the PMXAfrica self-paced pharmacometrics course and will run as a structured 12-week cohort with induction, weekly lessons, live tutorials, discussion forums, progress tracking, and completion certificates. Who should apply: The course is intended for researchers, clinicians, pharmacists, pharmacologists, statisticians, data scientists, regulators, postgraduate students, and early-career scientists who want to build foundational understanding of pharmacometrics and its applications in clinical pharmacology, drug development, therapeutic optimisation, and regulatory science. Applicants should be able to commit approximately 4-6 hours per week for self-study, exercises, tutorials, and discussion. Course content: The course covers core principles of pharmacometrics, pharmacokinetics, pharmacology, biostatistics, compartmental modelling, repeated dosing, PK-PD modelling, data analysis, non-compartmental analysis, and bioequivalence. Delivery Platform and Support: The course will be delivered through PMX Africa Moodle. Accepted participants will receive Moodle access instructions before induction. Moodle support: elearning@pmxafrica.org Application Requirements: Applicants are required to have: Certification: Participants who meet the PhM-2026 completion criteria will receive a certificate of completion from Pharmacometrics Africa. Cost: Free

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Research Paper: Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin-resistant tuberculosis

23 December 2025

Read the full paper here Abstract: Levofloxacin is a widely used antibiotic included in rifampicin-resistant tuberculosis (RR-TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR-TB. Plasma and breastmilk samples were collected over eight hours, ≥5 weeks postpartum. A single plasma sample was obtained from breastfed infants. Twenty women contributed paired plasma-breastmilk samples, 15 plasma concentrations from breastfed infants were available. Using nonlinear mixed-effects modelling, levofloxacin equilibrated rapidly between plasma and breastmilk (7.50 min half-life; 95% CI: 3.89–11.5), with a breastmilk: plasma ratio of 1.46 (95% CI: 1.40–1.52). The relative infant dose through breastfeeding was 6–8% of the recommended 15–20 mg/kg/day adult and paediatric dose, confirmed by low (but detectable) concentrations in some infants. It is unclear whether these low infant concentrations may be prophylactic or instead contribute to the development of drug resistance.  

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Upcoming Workshop: PBPK and QSP Modeling on OSP Suite V12 with Dr Stephan Schaller

14 July 2025

Date:🗓️ Tuesday 23 July, 13:00–17:00🗓️ Wednesday 24 July, 09:00–16:00📍 IDM Training Room, University of Cape Town, Faculty of Health Sciences About the speakerDr Stephan Schaller is the CEO of ESQlabs, a German-based consultancy specializing in physiologically-based pharmacokinetic (PBPK) and quantitative systems pharmacology (QSP) modeling. A leading figure in the development and application of the Open Systems Pharmacology (OSP) platform, Dr Schaller has led numerous training workshops across the globe and actively contributes to making PBPK and QSP modelling more transparent, reproducible, and accessible. About the workshopThis 1.5-day hands-on training will introduce key PBPK modelling principles using PK-Sim, followed by advanced model management using MoBi’s new modularization features in OSP Suite V12. Participants will gain practical experience in: Who should attend?Whether you are a beginner curious about PBPK modelling or an experienced modeler looking to explore the latest OSP Suite updates, this workshop is designed for: Cost: R319.00💸 The workshop includes catering and access to all training materials. Seats are limited – register early to secure your spot! https://shop.esqlabs.com/products/workshop-cape-town 🧠 About this seriesHosted by the PMXAfrica UCT Chapter, this event is part of our ongoing effort to share knowledge, present advances, and discuss best practices in pharmacometrics. We aim to highlight locally-relevant case studies and expand access to high-quality training in model-informed drug development.

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