News

[Webinar Series: Uganda Chapter] Causal Models to Support Better Decisions in Drug Development: PBPK/QSP, Part II

20 May 20254:00 PM – 5:00 PM EAT (1h) Register here About the speaker Jim Bosley, PhD has spent over 20 years advancing systems biology modeling and advocating its adoption in pharmaceutical research. Prior to joining Nova In Silico he founded and ran a systems biology modeling consulting company, Clermont, Bosley LLC, serving major pharma/biotech. Prior to this, Jim started the modeling practice at Rosa & Co. building the group from one to ten principals, with the title of Vice President of Modeling and Simulation.  We was Sr. Director of Software Products for Pharsight (now a Certara company), as a Consulting Engineer for Entelos and as a Senior Engineer in DuPont’s BioChemical Science and Engineering group. He has written several articles and book chapters on QSP modeling. Jim holds a PhD (Chem. E.) from the University of Texas at Austin, an MSc (E.E.) from the University of California-Irvine, and a BSc (Chem. E.) from the University of Wisconsin. He has taught courses, and is an affiliated faculty member, at the University of Delaware. As SVP Modeling and Simulation, Jim is supporting Nova In Silico’s expert modelers and programmers with both an understanding of the current state of the art technology, but also with innovative modeling ideas. About this series Sharing knowledge, presenting advances and discussing best practices in pharmacometrics, featuring locally-relevant case studies in application of PBPK and pop-PK Who should attend: Anyone interested in learning how pharmacometrics helps to enable safe and effective use of medication Cost: Totally Free –

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Nigeria Chapter Members Selected for High-Impact Learning Opportunities in Pharmacometrics and Clinical Pharmacology

The Nigeria Chapter of Pharmacometrics is pleased to highlight a significant step forward in the development of our local pharmacometrics capacity. Two of our members—Jacinta Nwogu-Attah and Babatunde Adeagbo—are embarking on enriching professional development journeys that promise to strengthen our collective expertise and impact. Advancing Skills Through Global Exposure Jacinta Nwogu-Attah has been selected as one of three inaugural fellows for the Africa Research Excellence Fund (AREF)-Genentech/Roche Research Development Fellowship. This opportunity will allow her to join the Clinical Pharmacology team at the cutting-edge Genentech laboratory in San Francisco, California. During her time at Genentech, Jacinta will work on a range of advanced pharmacometrics modelling projects, spanning pharmacokinetics (PK), pharmacokinetics/pharmacodynamics (PK/PD), and physiologically based pharmacokinetic (PBPK) modelling. This is more than an international experience; it is a focused opportunity to acquire technical skills that will directly contribute to strengthening research and application capacity within our Nigerian pharmacometrics community. Jacinta has expressed her commitment to leveraging this opportunity to support knowledge transfer and collaborative projects upon her return—an inspiring example of how global exposure can serve local development. Growing Capacity Through Professional Engagement In a similar spirit of growth, Babatunde Adeagbo has been awarded the Low and Middle-Income Country (LMIC) Award from the American Society for Clinical Pharmacology and Therapeutics (ASCPT). This award supports including researchers from underrepresented regions in global pharmacology dialogues, offering Babatunde access to training, mentorship, and scientific exchange at the highest levels. His participation will provide valuable insights into international trends in clinical pharmacology while reinforcing approaches

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Watch: Mechanistic Absorption Modeling: Enhancing Understanding and Prediction of Drug Performance Webinar

Recorded: 8 April 20254pm EAT / 3pm CEST (1h) About the Speaker Sandra Cvijic is a full professor at the Department of Pharmaceutical Technology and Cosmetology, University in Belgrade-Faculty of Pharmacy, Serbia. She holds a PhD in Medical Sciences – Pharmacy (2011) and Specialization in Pharmaceutical Technology (2015) from the University of Belgrade-Faculty of Pharmacy. She did postdoctoral research in biopharmaceutics at Johannes Gutenberg University in Mainz, Germany (2013), and was a visiting scientist at Heinrich-Heine University, Düsseldorf, Germany (2014) and Carol Davila University of Medicine and Pharmacy, Bucharest, Romania (2018). She has authored or co-authored more than 150 publications and presentations at national and international scientific meetings. She also held several seminars and workshops on PBPK/PBBM modeling. Her research interest has to do with biopharmaceutical characterization of drugs and drug products, modeling and simulation of drug absorption and disposition, drug performance in specific populations, bioperformance dissolution testing, in vitro-in vivo correlation, formulation and characterization of oral and inhalation drugs. About this series Sharing knowledge, presenting advances and discussing best practices in pharmacometrics, featuring locally-relevant case studies in application of PBPK and pop-PK Who should attend: Anyone interested in learning how pharmacometrics helps to enable safe and effective use of medication

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Protocol Paper: Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP)

Read the full paper here Abstract: This prospective observational study will enrol adult PLWH receiving amoxicillin, azithromycin, ciprofloxacin, rifampicin, isoniazid, or ceftriaxone. Concentrations of these antibiotics will be measured locally. TDM with dose adjustment will be performed in a subset of participants on TB treatment. Pharmacokinetic parameters will be estimated using non-linear mixed effects models.

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Perspective Paper: Appraising the visibility, relevance and impacts of clinical pharmacology

Read the full paper here Abstract: Clinical pharmacology (CP) used to be a strong medical and scientific field, but during the last three decades it seems to have lost some of its appeal. We reviewed the visibility, relevance and impact of CP and clinical pharmacologists across the globe and suggest ways to strengthen the discipline to address future pharmacotherapeutic challenges.

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Upcoming Webinar: Fundamentals of Physiologically Based Pharmacokinetic (PBPK) Modelling

Register Here Wednesday, 30 April 202514:00 West African Time Last month, we had an introduction to pharmacometrics. Join us as we continue our discussion on PBPK modelling. This webinar will cover components of PBPK models, data requirements, and an introduction to PBPK modelling softwares. Important Prerequisite: Install the PKSIM software using the provided installation instructions. About this Series The Pharmacometrics Africa (Nigeria Chapter) Webinar Series is designed to provide a structured learning experience on PBPK and Population Pharmacokinetics. The series will guide participants through fundamental concepts, model development, and real-world applications. Who Should Attend? Anyone interested in learning the fundamentals of pharmacometrics and its application in medication therapy: Academics, Researchers, Postgraduate students, and Undergraduate students.

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Exploring the fundamentals of PBPK and Population Pharmacokinetics: Nigeria Chapter March 2025 Webinar Recording

PMX Africa: Nigeria ChapterMarch 2025 Webinar Introduction to PBPK and Population Pharmacokinetics Recorded: Wednesday, March 26, 2025 This was an insightful session on Pharmacokinetic Modeling, where we explored the fundamentals of PBPK and Population Pharmacokinetics. This webinar covered key differences between these modelling approaches, their applications in drug development and clinical research, and how they enhance our understanding of drug behaviour in diverse populations. A special thank you to the speaker, Babajide Shenkoya and the 50+ participants who made this webinar a success. Stay tuned for more details about next month’s webinar! About the Speaker Babajide ShenkoyaBabajide holds a Bachelor of Pharmacy degree and a Master’s in Pharmaceutical Chemistry from Obafemi Awolowo University, where he focused on statistical and computational methods at the Translational Pharmacokinetic Research Group. He is currently a Doctoral candidate at the University of Maryland School of Pharmacy. His research interests include applying quantitative approaches, particularly pharmacometric techniques such as non-compartmental analysis (NCA), population pharmacokinetics (popPK), pharmacokinetics/pharmacodynamics (PK/PD), physiologically based pharmacokinetic (PBPK) modeling, and clinical trial simulations (CTS), to address critical questions in clinical practice and drug development. About Pharmacometrics Africa: Nigeria Chapter We are a group of scientists in Nigeria, who belong to the Pharmacometrics Africa Network, dedicated to advancing patient care through clinical pharmacology and pharmacometrics. Our mission is to optimize drug therapy and improve patient outcomes by leveraging modelling and simulation tools to understand drug behaviour and patient response by providing data-driven insights to guide treatment outcomes.

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Another year of Success: Celebrating the 2025 Graduates of the Clinical Assessors Programme

Pharmacometrics Africa, in collaboration with SAHPRA and the Department of Pharmacy and Pharmacology at the University of the Witwatersrand, marks the graduation of the fourth cohort of the Clinical Assessors Short Course — a programme designed to strengthen regulatory capacity across Africa. This 14-week certified course is part of an ongoing effort to build technical knowledge in assessment of clinical sections of regulatory dossiers. The course has a primary focus on the development of professionals working in African National Regulatory Agencies, while also welcoming private sector regulatory scientists. Accredited by Wits University, the course brings together regulators, academics, patient advocates, and industry stakeholders to promote shared understanding and practical skills in clinical assessment. The most recent cohort included participants from National Regulatory Authorities in Botswana, Ethiopia, Ghana, Kenya, Namibia, Rwanda, South Africa, Tanzania, Zambia, and Zimbabwe. Their participation reflects a growing interest across the continent in strengthening regulatory systems. “This training course has once again brought together a diverse group of regulators, academic experts, and industry professionals to engage in honest, solutions-oriented dialogue. The outcomes speak directly to better patient access and improved therapeutic interventions,” added Professor Colin Pillai, CEO of Pharmacometrics Africa. “As we mark the fourth cycle of this impactful programme, we are reminded that investing in regulatory training is an investment in patient safety. These graduates are shaping a healthier, safer future for the continent,” said Dr Boitumelo Semete-Makokotlela, CEO of SAHPRA. Professor Yahya E. Choonara of the University of the Witwatersrand emphasised, “We are proud to

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[Webinar Series: Uganda Chapter] Mechanistic Absorption Modeling: Enhancing Understanding and Prediction of Drug Performance

8 April 20254pm EAT / 3pm CEST (1h) Register here About the author Sandra Cvijic is a full professor at the Department of Pharmaceutical Technology and Cosmetology, University in Belgrade-Faculty of Pharmacy, Serbia. She holds a PhD in Medical Sciences – Pharmacy (2011) and Specialization in Pharmaceutical Technology (2015) from the University of Belgrade-Faculty of Pharmacy. She did postdoctoral research in biopharmaceutics at Johannes Gutenberg University in Mainz, Germany (2013), and was a visiting scientist at Heinrich-Heine University, Düsseldorf, Germany (2014) and Carol Davila University of Medicine and Pharmacy, Bucharest, Romania (2018). She has authored or co-authored more than 150 publications and presentations at national and international scientific meetings. She also held several seminars and workshops on PBPK/PBBM modeling. Her research interest has to do with biopharmaceutical characterization of drugs and drug products, modeling and simulation of drug absorption and disposition, drug performance in specific populations, bioperformance dissolution testing, in vitro-in vivo correlation, formulation and characterization of oral and inhalation drugs. About this series Sharing knowledge, presenting advances and discussing best practices in pharmacometrics, featuring locally-relevant case studies in application of PBPK and pop-PK Who should attend: Anyone interested in learning how pharmacometrics helps to enable safe and effective use of medication Cost: Totally Free –

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Lancement du Tunisia Chapter de Pharmacometrics Africa !

Nous sommes ravis d’annoncer la création du Tunisia Chapter de Pharmacometrics Africa, le tout premier chapitre francophone de cette communauté africaine !  La pharmacométrie joue un rôle clé dans l’optimisation des traitements médicaux grâce à des approches basées sur des modèles mathématiques et statistiques. Pourtant, cette discipline reste encore peu développée en Tunisie et dans de nombreux pays francophones. C’est pour répondre à ce besoin que nous avons décidé de créer ce chapitre ! Plus d’informations : Rejoignez-nous dès aujourd’hui !Que vous souhaitiez apprendre, contribuer ou simplement échanger, nous serions ravis de vous compter parmi nous. Contactez-nous dès maintenant et faisons avancer ensemble la pharmacométrie en Tunisie et au-delà ! English Version: We are delighted to announce the creation of the Tunisia Chapter of Pharmacometrics Africa, the very first French-speaking chapter of this African community! More Information (FR) Pharmacometrics plays a key role in optimising medical treatments using approaches based on mathematical and statistical models. However, this discipline is still underdeveloped in Tunisia and in many other French-speaking countries. It is in response to this need that we have decided to create this chapter. Join us today!Whatever your interest, whether you want to learn, contribute or simply exchange ideas, we’d love to have you on board. Contact us today and let’s work together to advance pharmacometrics in Tunisia and beyond!

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